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During my residence in the Amazon district I took every opportunity of determining the limits of species, and I soon found that the Amazon, the Rio Negro and the Madeira formed the limits beyond which certain species never passed. The native hunters are perfectly acquainted with this fact, and always cross over the river when they want to procure particular animals, which are found even on the ...
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Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1993
ISSN: 0021-9738
DOI: 10.1172/jci116743